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02/20/2025

BetaGlue® Completes Exclusive Global Agreement With ArtivionTM Securing Supply Of BioGlue® For The Manufacture Of BetaGlue’s YntraDose® Oncology Platform

YntraDose Glue Syringe Size S

Milan, February 20th 2025 – BetaGlue® Therapeutics S.p.A. (“BetaGlue”), a clinical-stage oncology company developing an innovative radiotherapy platform for the targeted and personalised treatment of unresectable solid tumours, called YntraDose®, announced today that it has entered into an agreement for the exclusive global supply of BioGlue® for use in YntraDose.

Artivion, Inc. (“Artivion”) manufactures, markets, and sells BioGlue in over 80 countries as a surgical sealant for use in cardiovascular applications. Since its launch in 1998, BioGlue has been used in more than 2.5 million procedures worldwide and over 500 peer-reviewed preclinical and clinical papers have been published about BioGlue.

Artivion and BetaGlue have entered into a long-term exclusive global supply agreement securing the manufacture and supply of BioGlue. YntraDose enables minimally-invasive needle-based focal high-radiation treatment of solid tumours by ‘holding’ and ‘gluing’ radioactive microspheres at the site of administration.

“We are delighted to formalise our long-term mutual commitment to collaborate with Artivion and leverage Artivion’s surgical sealant technical expertise to bring YntraDose to patients in tough-to-treat solid tumour cancers. I’d like to personally thank the team at Artivion for all of their support to date and I very much look forward to bringing these potentially life-changing minimally-invasive targeted therapies to patients.” said Dr Colin Story, Chief Executive Officer of BetaGlue.

About BetaGlue Therapeutics S.p.A.

BetaGlue Therapeutics S.p.A. is an Italian clinical-stage oncology company developing a novel radiotherapy platform technology for the localised and targeted treatment of unresectable solid tumours called YntraDose®. BetaGlue enjoys the support of a global Clinical Advisory Board, as well as of leading national and international advisers, in the development of its products. Visit our website, www.betaglue.com. Visit our LinkedIn page here.

About Artivion Inc.

Headquartered in suburban Atlanta, Georgia, Artivion, Inc. is a medical device company focused on developing simple, elegant solutions that address cardiac and vascular surgeons’ most difficult challenges in treating patients with aortic diseases. Artivion’s four major groups of products include: aortic stent grafts, surgical sealants, On-X mechanical heart valves, and implantable cardiac and vascular human tissues. Artivion markets and sells products in more than 100 countries worldwide. For additional information about Artivion, visit its website, www.artivion.com.